Artesunate Mitigates Sepsis-Induced Acute Kidney Injury via Lactate/AMPK/mTOR-Regulated Autophagy Based on Multi-Omics
The findings suggest that ART may mitigate inflammation and oxidative stress while improving renal function in S-AKI by modulating the lactate/AMPK/mTOR pathway and inhibiting excessive autophagy.
Authors
- Jiajia Duan (ORCID: https://orcid.org/0000-0002-7587-1789)
- Ying Li (ORCID: https://orcid.org/0000-0002-3925-1806)
- Menglu Chen (ORCID: https://orcid.org/0000-0003-0052-9310)
- Xuejiao Li (ORCID: https://orcid.org/0000-0002-5391-6448)
- Ran Guo (ORCID: https://orcid.org/0000-0002-9424-8140)
- Tao Jiang (ORCID: https://orcid.org/0000-0001-8132-8945)
- Lei Zhang (ORCID: https://orcid.org/0009-0003-1693-0093)
- Jia Guo (ORCID: https://orcid.org/0000-0002-3701-8867)
- Peipei Du (ORCID: https://orcid.org/0009-0003-9851-8392)
- Hetao Chen
Institutions
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/dddt.s525701
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06