Association of Soluble Immune Checkpoint Molecules <scp>PD1</scp> and 4‐<scp>1BB</scp> With <scp>CTLA</scp>‐<scp>4Ig</scp> Treatment Response in Early Rheumatoid Arthritis
High plasma levels of sPD1 and s4-1BB are associated with good response to CTLA-4Ig with MTX therapy in patients with eRA. A combination of sPD1 or 4-1BB levels and the proportions of PD1<sup>+</sup> TFh cells in blood at baseline has potential for predicting remission after CTLA-4Ig treatment.
Authors
- Tilia Selldén (ORCID: https://orcid.org/0009-0006-7969-4157)
- Kerstin Andersson (ORCID: https://orcid.org/0000-0001-6302-7006)
- Ronald van Vollenhoven (ORCID: https://orcid.org/0000-0001-6438-8663)
- Gerður Gröndal (ORCID: https://orcid.org/0009-0009-6751-3330)
- Kristina Lend (ORCID: https://orcid.org/0000-0001-5037-5546)
- Till Uhlig (ORCID: https://orcid.org/0000-0002-6881-9552)
- Anna‐Karin Hultgård Ekwall (ORCID: https://orcid.org/0000-0001-8236-6089)
- Kim Hørslev‐Petersen (ORCID: https://orcid.org/0000-0002-5475-7610)
- Dan Nordström
- Cristina Maglio (ORCID: https://orcid.org/0000-0002-3786-5767)
- Björn Guðbjörnsson (ORCID: https://orcid.org/0000-0003-4631-6505)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Jon Lampa (ORCID: https://orcid.org/0000-0002-7856-3968)
- Anna Rudin (ORCID: https://orcid.org/0000-0002-4137-1276)
- Anna‐Carin Lundell (ORCID: https://orcid.org/0000-0002-4303-8266)
- Inger Gjertsson (ORCID: https://orcid.org/0000-0002-9301-4844)
Institutions
- University of Copenhagen (DK)
- Karolinska University Hospital (SE)
- University of Iceland (IS)
- University of Southern Denmark (DK)
- Sahlgrenska University Hospital (SE)
- Glostrup Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- National University Hospital of Iceland (IS)
- Diakonhjemmet Hospital (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/acr2.70069
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet