Downregulation of Mfn2 Contributes to Chronic Postsurgical Pain via Inducing the Pyroptosis of <scp>GABAergic</scp> Neurons in the Spinal Cord
Our study demonstrated that downregulation of Mfn2 leads to mitochondrial dysfunction and ROS accumulation, which promotes the pyroptosis of spinal GABAergic neurons and the development of chronic pain.
Authors
- Tongtong Liu
- Chang Jun Zhu (ORCID: https://orcid.org/0009-0007-2771-5507)
- Wenlong Yao (ORCID: https://orcid.org/0000-0002-9263-294X)
- Li Wan (ORCID: https://orcid.org/0000-0003-1004-654X)
- Xiao He (ORCID: https://orcid.org/0009-0000-9059-3919)
- Yuye Chen (ORCID: https://orcid.org/0009-0005-6940-1456)
- Yingjie Hu (ORCID: https://orcid.org/0000-0002-5260-4151)
- Hu Zang
- Li Li (ORCID: https://orcid.org/0000-0002-2441-1774)
Institutions
- Hubei University of Chinese Medicine (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/cns.70508
- Citations
- 5
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China