[Chinese expert consensus on the diagnosis and treatment of adult Langerhans cell histiocytosis (2025)].

Langerhans cell histiocytosis (LCH) is a clonal hematologic neoplasm primarily characterized by the activation of the mitogen-activated protein kinase (MAPK) signaling pathway; it can involve any organ or system and presents with diverse clinical manifestations. Based on current evidence-based medicine and combined with domestic clinical experience, this consensus elaborates on the pathogenesis, clinical manifestations, diagnosis, treatment, and efficacy evaluation of adult LCH, aiming to provide professional guidance for its diagnosis and treatment in China.