The stem bark decoction of Myrianthus arboreus P. Beauv. (Cecropiaceae) shows anti-uterine leiomyoma effects in Wistar rat

Uterine fibroids are non-cancerous tumors that originate from the smooth muscular wall of the uterus. They may cause severe symptoms, such as chronic pelvic pain, heavy menstrual bleeding, painful intercourse, frequent urination, back pain and obstetric complications (embryo implantation failure, fetal growth restriction, miscarriages, preterm delivery, and fertility impairment). The exact cause is not known, but hormonal changes may play an important role. Treatment options depend on the symptoms and desire to preserve the uterus, and may include medication, minimally invasive procedures and surgery. Their associated risks and limitations fuel searching for conservative alternatives. This study investigates the anti-uterine fibroid potential of the giant yellow mulberry (Myrianthus arboreus P. Beauv.) in rat. Consuming boiled M. arboreus stem bark in water reduced uterine wall thickness, inflammation, and collagen deposition, and increased the ability of the uterus to fight cell damage. Thus, this extract may prevent or shrink uterine fibroids by reducing uterine swelling, fibrosis and excessive cell growth.