Endothelial plasticity in atrial fibrosis by integrating single-cell sequencing and genetic lineage tracing
Our findings demonstrate that EndoMA-derived TGF-β1 critically regulates FB function and drives atrial fibrosis progression. Targeting endothelial-specific pathways represents a promising therapeutic strategy for attenuating atrial fibrosis in AF pathogenesis.
Authors
- Chunyu Yu (ORCID: https://orcid.org/0000-0003-0712-536X)
- Zhe Zheng (ORCID: https://orcid.org/0000-0002-9162-6492)
- Hanning Liu (ORCID: https://orcid.org/0000-0002-9760-207X)
- F Li (ORCID: https://orcid.org/0000-0001-5588-6206)
- Jianqiu Pei (ORCID: https://orcid.org/0000-0002-7935-0884)
- Jun Li (ORCID: https://orcid.org/0000-0003-4820-5251)
- Xiaoyi Wang (ORCID: https://orcid.org/0000-0003-2974-9456)
- Yan Zhao
- Juncheng Wang (ORCID: https://orcid.org/0009-0007-2185-9526)
- Zhiwei Zeng (ORCID: https://orcid.org/0000-0001-9161-7652)
- Peng Wang (ORCID: https://orcid.org/0000-0002-5716-9937)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-05-21
- DOI
- https://doi.org/10.1093/eurheartj/ehaf372
- Citations
- 7
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.58