Effects of prenatal supplementation with probiotics on the development of experimental periodontitis in pregnant mice
This study investigated whether prenatal probiotics could protect pregnant mice and their fetuses from the harmful effects of periodontitis. Pregnant mice were divided into four groups based on whether they had gum disease, received probiotics, had both, or were in the control group. Periodontitis alone caused smaller, lighter fetuses, altered placentas, reduced jawbone volume, and thinner intestinal tissue. However, probiotic treatment improved these outcomes: fetuses were healthier, placentas and intestines showed less damage, and jawbones retained more bone. Probiotics also reduced inflammation in the gums and placenta. These results suggest that probiotics may help mitigate the negative effects of periodontitis during pregnancy, benefiting both the mother and the baby.
Authors
- Cristhiam de Jesus Hernandez Martinez (ORCID: https://orcid.org/0000-0002-8053-8366)
- Daniela Bazan Palioto (ORCID: https://orcid.org/0000-0003-1913-0895)
- Pedro Henrique Félix Silva (ORCID: https://orcid.org/0000-0002-7583-7046)
- Amanda Ferreira Gonzalez (ORCID: https://orcid.org/0000-0001-8611-7645)
- Renato Côrrea Viana Casarin (ORCID: https://orcid.org/0000-0003-1743-5855)
- Michel Reis Messora (ORCID: https://orcid.org/0000-0001-8485-9645)
- Flávia Aparecida Chaves Furlaneto (ORCID: https://orcid.org/0000-0002-8072-3983)
- Sérgio Luiz de Souza Salvador (ORCID: https://orcid.org/0000-0002-4867-7294)
- F. Fabris (ORCID: https://orcid.org/0009-0009-0345-5004)
Institutions
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
Publication Details
- Journal
- Journal of Periodontology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/jper.24-0597
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo