Association of Creatine Use with Chronic Exertional Compartment Syndrome in a Distance Runner: A Case Report

Chronic exertional compartment syndrome (CECS) of the lower extremity is a condition that affects runners and can result in significant time loss from athletic activity. While the etiology of CECS is often multifactorial, research on the relationship between CECS and supplementation is sparse. This case report describes a runner who developed lower leg CECS following use of creatine and provides considerations of risk factors and differential diagnoses for CECS.