Acute myeloid leukemia with translocations involving the <i>KMT2A</i> gene in twins as a model for the study of leukemogenesis: clinical case reports and genetic characteristics
Familial cases of acute leukemia in children are very rare and are mainly reported in cases of genetically determined predisposition syndromes (mutations in the RUNX1, ETV6, ANKRD26, GATA2, SAMD9/SAMD9L, CEBPA genes) which have been well characterized in the last 15 years. In twins, leukemia is even more rare and is of particular interest for the study of leukemogenesis patterns and evolution of leukemic subclones. Here, we report about three pairs of twins: in one pair, KMT2A-r-leukemia was diagnosed simultaneously, while in the other two cases the second child remained healthy despite the development of KMT2A-r-leukemia in their twin. The patients’ parents gave consent to the use of their children's data, including photographs, for research purposes and in publications.
Authors
- А. Н. Казакова (ORCID: https://orcid.org/0000-0002-1085-4646)
- Alexander M. Popov (ORCID: https://orcid.org/0000-0002-0889-6986)
- Alexey Maschan (ORCID: https://orcid.org/0000-0002-0016-6698)
- I. Ya. Tomilin
- S. A. Kashpor (ORCID: https://orcid.org/0000-0002-5220-7412)
- М. В. Натрусова (ORCID: https://orcid.org/0000-0003-4244-7110)
- Olga Soldatkina (ORCID: https://orcid.org/0000-0001-7755-0228)
- Г. О. Бронин (ORCID: https://orcid.org/0000-0002-0694-3996)
- У. Н. Петрова (ORCID: https://orcid.org/0000-0002-1258-8281)
- T. V. Konyukhova
- D. D. Baydildina (ORCID: https://orcid.org/0000-0001-7130-8596)
- M. V. Gaskova (ORCID: https://orcid.org/0000-0002-3277-9018)
- Yulia Olshanskaya (ORCID: https://orcid.org/0000-0002-2352-7716)
- D. А. Venyov (ORCID: https://orcid.org/0000-0002-0183-1530)
- K. S. Antonova (ORCID: https://orcid.org/0000-0002-6001-2746)
- Elena Zerkalenkova (ORCID: https://orcid.org/0000-0001-9634-5828)
- M. Е. Dubrovina (ORCID: https://orcid.org/0000-0001-8228-4876)
- Dmitry Balashov (ORCID: https://orcid.org/0000-0003-2689-0569)
- С. А. Лебедева
- Z. Z. Askerova
Institutions
- Russian Children's Clinical Hospital (RU)
- Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (RU)
Publication Details
- Journal
- Pediatric Hematology/Oncology and Immunopathology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.24287/1726-1708-2025-24-1-167-174
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00