Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling
Our findings highlight the role of GaMSC-Exos in mediating the intercellular transfer of miRNA-191-5p, which facilitates the PMT of glioma. The process underlying the enhanced aggressiveness and PMT is driven by miR-191-5p, promoting glioma progression by targeting PTEN and activating the PI3K/AKT signaling pathway.
Authors
- Wei Xiang (ORCID: https://orcid.org/0000-0002-8331-1407)
- Sumeng Li
- Pengfei Yan (ORCID: https://orcid.org/0000-0001-9077-6854)
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0001-8844-0286)
- Yan Zhou (ORCID: https://orcid.org/0000-0002-2713-4442)
- Peng Lv (ORCID: https://orcid.org/0000-0001-9219-3337)
- Peng Fu (ORCID: https://orcid.org/0000-0002-4381-9206)
- Zhen Zhao (ORCID: https://orcid.org/0000-0003-0044-5512)
- Yanbin Zhang
- Wenjie Wu (ORCID: https://orcid.org/0000-0001-5888-1208)
- Haofei Wang (ORCID: https://orcid.org/0000-0001-5337-2420)
- Zhen Liu (ORCID: https://orcid.org/0000-0002-1401-9621)
- Xing Huang (ORCID: https://orcid.org/0000-0002-2875-9444)
Institutions
- Union Hospital (HK)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/ijn.s515771
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42