Study on association of Troponin-I level in adult NS1 positive dengue patients in a tertiary care hospital of Bangladesh

Background: Dengue fever is a viral disease which is transmitted by Aedes mosquitoes.It has become a significant public health concern in Bangladesh.The clinical symptoms of dengue fever are often selflimiting.But severe cases can lead to different types of complications especially cardiac complications.Troponin-I is a cardiac biomarker which is elevated in myocardial injury.Its association with dengue virus infection, particularly the dengue patients who are NS1 antigen positive, remains understudied.Objective: This objective of this study is to find out the association of Troponin-I level with dengue infection in adult NS1 positive dengue patients in a tertiary care hospital in Bangladesh.Methods: A cross-sectional study was conducted on adult patients diagnosed with dengue fever and confirmed by positive dengue NS1 antigen at a tertiary care hospital.The levels of Troponin-I were measured and correlated with clinical symptoms, duration of disease, and other relevant laboratory findings.Data analysis included statistical methods to evaluate the significance of Troponin-I as a marker for cardiac involvement in dengue.Results: The study examined the demographic data, clinical characteristics, and laboratory findings of 52 participants, divided into Troponin-I positive (n=16) and Troponin-I negative (n=36) groups.Significant differences were observed in gender distribution and socioeconomic status.Troponin-I positivity was most prevalent among older individuals (>46 years, p < 0.001).Clinical parameters showed strong associations with symptoms such as chest pain, headache, and vomiting (p < 0.001).Additionally, laboratory analysis identified significant variations in hemoglobin, RBC count, serum bilirubin, SGPT, and creatinine levels (p < 0.05).These findings highlight key clinical and laboratory distinctions between Troponin-I positive and negative groups, offering valuable insights into their diagnostic and prognostic significance.Conclusion: This study shows distinct demographic, clinical, and laboratory patterns among patients of dengue fever with positive dengue NS1 and positive Troponin-I.Troponin-I positivity in dengue patients is significantly associated with older age, clinical symptoms and laboratory abnormalities, while dengue NS1 positive younger individuals with negative Troponin-I were found to developed milder symptoms.Gender differences and symptoms variability underscore the need for tailored, age-specific diagnostic and therapeutic strategies.