Hepatitis A Virus-Induced Macrophage Activation Syndrome in a Child: A Case Report

Macrophage activation syndrome (MAS) is characterized by high fever, hepatosplenomegaly, lymphadenopathy, cytopenia, liver dysfunction, and coagulopathy.MAS is a group of hemophagocytic disorders that can be primary or secondary.Primary hemophagocytic lymphohistiocytosis (HLH) is due to an underlying genetic abnormality.Secondary HLH is commonly associated with autoimmune diseases, malignancies, or infections.Although the incidence of hepatitis A virus (HAV) is high in children, there are few cases reports of HAV-associated hemophagocytic syndrome.