Ultra-hypofractionation for the treatment of macroscopic prostate bed recurrence: a focus on stereotactic radiotherapy and brachytherapy

Ultra-hypofractionated salvage radiotherapy offers effective disease control with manageable toxicity for selected patients and may defer systemic therapy. Further studies are needed to standardize imaging, biopsy confirmation, dose escalation, and systemic treatment integration. Prospective, randomized studies are crucial to define optimal modality, target volume, and patient selection criteria before widespread adoption.