Inhibition of Aspartate β-Hydroxylase Enhances Anti-Tumor Immunity
ASPH inhibition stimulated T-cell-mediated adaptive immunity induced by DNA vaccination. Different types of lymphoid and myeloid cells were likely involved in the activated immune response that was efficient against tumors with MHC-I downregulation, which are often resistant to T-cell-based therapies. Due to different types of activated immune cells, ASPH inhibition could improve immunotherapy for tumors with various MHC-I expression levels.
Authors
- Shweta Dilip Johari (ORCID: https://orcid.org/0000-0001-6265-8949)
- Ingrid Poláková (ORCID: https://orcid.org/0000-0003-1315-0924)
- Mark Olsen (ORCID: https://orcid.org/0000-0003-2871-1923)
- Michal Šmahel (ORCID: https://orcid.org/0000-0002-0366-4932)
- Carlos Eduardo Madureira Trufen (ORCID: https://orcid.org/0000-0003-1216-0418)
- Katerina Krausova
- Barbora Zucha
Institutions
- Midwestern University (US)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/itt.s530987
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00