Experimental Evaluation of the Effect of Low Molecular Weight Chitosan on the Aseptic Wound Process

The work provides a comparative experimental evaluation of the effectiveness of low-molecular-weight chitosan in an aseptic wound process.The study was conducted on an in vivo model simulating the acute phase of the aseptic wound process (1 st day postinjury) and the phase of regenerative-plastic processes (7 th day post-injury).Both models were performed on mice and simulate aseptic wounds in plastic surgery, injection cosmetology, and contour plastic surgery.The effectiveness of low-molecular-weight chitosan on the acute phase of the wound process and the regenerative-plastic processes of healing is demonstrated in comparison with Traumeel Cosmo Gel, which contains a composition of medicinal plant extracts and is used in professional cosmetology during the healing and recovery period of the skin after aesthetic procedures (facial cleansing, mesotherapy, bio revitalization, injection procedures).The obtained results showed that low molecular weight chitosan possesses not only high wound healing activity but also powerful anti-inflammatory and anti-edema effects.At the same time, its influence on the aseptic wound process is accompanied by the full regeneration of all skin structures without excessive fibrillogenesis.When using Traumeel Cosmo Gel, on the contrary, there is a combination of active collagen synthesis against the background of an inflammatory reaction, which is the pathophysiological basis for the formation of scar complications.