Hospitalization Due to Febrile Urinary Tract Infection After Prostate Biopsy: A Comparative Analysis of 1805 Cases

Purpose: Patients with a history of urinary tract infection, antibiotic use, hospital admission, bacteriuria, diabetes mellitus, or other comorbidities may be at increased risk of infectious complications (10).Oral or intravenous antibiotics are essential before TR-PB.Cephalosporines could be a good alternative to fluoroquinolones for TR-PB prophylaxis.This study aims to show the cause of hospitalization due to febrile urinary tract infection after TR-PB. Methods:We performed a total of 1805 prostate biopsies in the above-mentioned period.Two groups of patients were formed based on their infection status.Group 1, 1748 patients had no infectious complications after TR-PB.Group 2, 57 patients had infections related to the prostate biopsy procedure.The primary endpoint was the development of infection-related complications, including microbiologically confirmed urinary tract infection (UTI) and/or bacteremia.Secondary outcomes assessed included bacteriuria, bacteremia, hospitalizations related to infection.Results: There were significant differences between the two arms in terms of Charlson comorbidity indexes, core number, diabetes mellitus, hypertension, IPSS, history of urinary tract infection, prior biopsy history (p < 0.05).Multivariate Cox regression analysis revealed that diabetes mellitus (HR 2.567, 95% CI 1.367-4.821,p < 0.003), hypertension (HR 3.842, 95% CI 2.176-6.782,p < 0.001), history of urinary tract infection (HR 3.526,, p < 0.005) and core number (HR 1.278, 95% CI 1.095-1.491,p < 0.002) were independent predictors of infection after prostate biopsy. Conclusion:Hypertension, diabetes mellitus, history of urinary tract infection and core number are independent risk factors for infection after TR-PB.