Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer
Our findings indicate that MDK promotes cell proliferation and chemotherapeutic resistance by activating the AKT pathway in SCLC cells. Therefore, MDK may be a potential therapeutic and diagnostic target for SCLC.
Authors
- Megumi Furuta (ORCID: https://orcid.org/0000-0002-1291-3988)
- Hidenori Kitai (ORCID: https://orcid.org/0000-0001-6372-846X)
- Shotaro Ito
- Junko Kikuchi
- Kanako C. Hatanaka (ORCID: https://orcid.org/0009-0008-9596-9661)
- Jun Sakakibara‐Konishi (ORCID: https://orcid.org/0000-0003-4333-8100)
- Daisuke Morinaga (ORCID: https://orcid.org/0000-0003-2810-4293)
- Takuro Noguchi (ORCID: https://orcid.org/0000-0003-1913-1038)
- Kyoko Hida (ORCID: https://orcid.org/0000-0002-7968-6062)
- Eiki Kikuchi (ORCID: https://orcid.org/0000-0003-4098-6321)
- Yutaka Hatanaka (ORCID: https://orcid.org/0000-0003-3128-1477)
- Hirofumi Takahashi
- Kosuke Tsuji (ORCID: https://orcid.org/0000-0003-4851-3721)
- Mineyoshi Sato (ORCID: https://orcid.org/0000-0002-6906-581X)
- Tetsuaki Shoji
- Satoshi Konno
- Masahiro Kashima
Institutions
- Sapporo Medical University (JP)
- Hokkaido University (JP)
- Hokkaido University Hospital (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/cam4.71034
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hokkaido University