Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis
Our MR analyses robustly demonstrate bidirectional causality: depression is a risk factor for TBI (OR = 1.137, 95% CI = 1.019-1.271), and TBI subsequently increases depression risk (OR = 1.083, 95% CI = 1.036-1.131), advocating integrated clinical monitoring.
Authors
- Chuanxiong Li (ORCID: https://orcid.org/0000-0002-7511-9933)
- Ying Shi (ORCID: https://orcid.org/0000-0002-8871-6489)
- Xiaohua Ke (ORCID: https://orcid.org/0000-0001-7839-9777)
- Qianwen Ruan
- Lei Pan (ORCID: https://orcid.org/0000-0003-3724-1783)
- B H Wang (ORCID: https://orcid.org/0000-0003-4501-7685)
- Shi‐Ping Wang (ORCID: https://orcid.org/0000-0002-2574-6752)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7769-7377)
- Tong Sun (ORCID: https://orcid.org/0000-0002-7435-9193)
- Geng Li (ORCID: https://orcid.org/0000-0002-7342-4539)
- Meihua Qiu (ORCID: https://orcid.org/0000-0001-6803-5582)
- Xu Yang
Institutions
- Tongji University (CN)
- Yunnan University (CN)
- Kunming Medical University (CN)
- Second People's Hospital of Yunnan Province (CN)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/brb3.70669
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00