Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study
By synergizing network pharmacology, 4D-FastDIA proteomics, and experimental validation, this study pioneers the demonstration that ZDZX alleviates IgAV via multi-target inhibition of NET-driven thromboinflammation.
Authors
- Yanqiu Fang
- Minghang Yang
- Xiaozheng Duan (ORCID: https://orcid.org/0000-0002-0273-1259)
- Xiaochun Feng (ORCID: https://orcid.org/0000-0001-5780-2811)
- Xiaofang Zhang (ORCID: https://orcid.org/0000-0001-9866-2018)
Institutions
- People 's Hospital of Jilin Province (CN)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/jir.s522082
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00