Transcriptomic Insights into Adaptive Strategies of Klebsiella pneumoniae Co-Producing KPC-2 and NDM-5 Carbapenemases Under Meropenem Stress
<i>bla</i> <sub>KPC-2</sub> and <i>bla</i> <sub>NDM-5</sub> co-producing <i>K. pneumoniae</i> employ a two-pronged resistance strategy: <i>bla</i> <sub>NDM-5</sub> plasmid amplification ensures enzymatic overdose, while biofilm induction creates physical barriers. These findings decode the survival strategies of pan-resistant pathogens and inform novel therapeutic approaches that target plasmid stability and biofilm disruption.
Authors
- Ziheng Xu (ORCID: https://orcid.org/0000-0001-6303-5823)
- Xiaoyan Cao (ORCID: https://orcid.org/0000-0002-3188-6663)
- Jiaxin Tang (ORCID: https://orcid.org/0000-0002-7210-5405)
- Peibo Yuan (ORCID: https://orcid.org/0000-0001-5061-0331)
- Mingyuan Zou (ORCID: https://orcid.org/0000-0001-6140-981X)
- Jiacheng Ding (ORCID: https://orcid.org/0000-0002-8732-5339)
- Hui-Min Zhang (ORCID: https://orcid.org/0000-0002-9327-7708)
- Lijuan Lin (ORCID: https://orcid.org/0000-0002-8305-0294)
- Wanting Liu (ORCID: https://orcid.org/0000-0003-0354-9069)
- Dingqiang Chen (ORCID: https://orcid.org/0000-0001-8717-1651)
- Li-Ting Dai
- Yingyi Cao
- Jiahui Ling
- Zhirou Xiao
- Z Chen
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhujiang Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/idr.s521566
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China