Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study
Neuroinflammation is elevated in Down syndrome (DS) versus age-matched non-DS controls. Neuroinflammation in DS shows a different pattern depending on the brain region. [<sup>11</sup>C]PK11195 uptake has a positive monotonic association with amyloid burden.
Authors
- Daniele de Paula Faria (ORCID: https://orcid.org/0000-0002-1766-2786)
- Artur Martins Coutinho (ORCID: https://orcid.org/0000-0002-5555-4583)
- Cláudia Lopes Carvalho (ORCID: https://orcid.org/0000-0001-7128-8644)
- Lídia Emmanuela Wiazowski Spelta (ORCID: https://orcid.org/0000-0001-6526-2915)
- Orestes Vicente Forlenza (ORCID: https://orcid.org/0000-0002-6962-5899)
- Suely Kazue Nagahashi Marie (ORCID: https://orcid.org/0000-0003-4419-7928)
- Carlos Alberto Buchpiguel (ORCID: https://orcid.org/0000-0003-0956-2790)
- Dimitri Brigide de Almeida Mantovani (ORCID: https://orcid.org/0000-0003-4883-4680)
- Laura C. Oliveira
Institutions
- Universidade de São Paulo (BR)
- Centrus Diagnósticos por Imagem (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70449
- Citations
- 1
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo