Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset
The PREPARE hypoxemia risk score, comprising five easily available characteristics, has the potential to be used to identify hypoxemia in children with pneumonia with a fair degree of certainty for use in health facilities without pulse oximetry. Its implementation would require careful consideration to limit the burden of inappropriate referrals on patients and the health system. Further external validation in community settings in low- and middle-income countries is required.
Authors
- Mala Rakoto‐Andrianarivelo (ORCID: https://orcid.org/0000-0001-6767-9554)
- Gláucia Paranhos‐Baccalà (ORCID: https://orcid.org/0000-0002-6369-5837)
- Shinjini Bhatnagar (ORCID: https://orcid.org/0000-0003-1703-5296)
- Nitya Wadhwa (ORCID: https://orcid.org/0000-0002-9435-1842)
- Pagbajabyn Nymadawa (ORCID: https://orcid.org/0000-0002-3189-2772)
- Philippe Vanhems (ORCID: https://orcid.org/0000-0003-3188-1456)
- Emmanuel Addo‐Yobo (ORCID: https://orcid.org/0000-0003-0038-2531)
- Yasir Bin Nisar (ORCID: https://orcid.org/0000-0002-9720-5699)
- Tor Arne Strand (ORCID: https://orcid.org/0000-0002-4038-151X)
- Eric D. McCollum (ORCID: https://orcid.org/0000-0002-1872-5566)
- Satinder Aneja (ORCID: https://orcid.org/0000-0001-9635-8792)
- Graciela Russomando
- Jean W. Pape (ORCID: https://orcid.org/0000-0002-2948-2774)
- Noel Chisaka
- Marta Coelho Nunes (ORCID: https://orcid.org/0000-0003-3788-878X)
- Alexey Clara (ORCID: https://orcid.org/0000-0003-3779-3449)
- Rakesh Lodha (ORCID: https://orcid.org/0000-0003-2608-1163)
- Vanessa Rouzier (ORCID: https://orcid.org/0000-0002-9672-9474)
- Rainer Tan (ORCID: https://orcid.org/0000-0002-9273-9632)
- Valentina Picot
- Ashish Bavdekar (ORCID: https://orcid.org/0009-0006-9466-4095)
- Patricia L. Hibberd (ORCID: https://orcid.org/0000-0002-7455-8117)
- Kerry-Ann O’Grady (ORCID: https://orcid.org/0000-0002-8159-2620)
- Arjun Chandna (ORCID: https://orcid.org/0000-0003-1313-7922)
- Romina Libster
- Ngoc Tuong Vy Nguyen
- Marilla Lucero (ORCID: https://orcid.org/0000-0003-3794-3128)
- Monidarin Chou
- Mathuram Santosham
- Mark I. Neuman
- Shabir Ahmed Madhi (ORCID: https://orcid.org/0000-0002-7629-0636)
- Carina King (ORCID: https://orcid.org/0000-0002-6885-6716)
- Fenella Beynon (ORCID: https://orcid.org/0000-0002-4758-8847)
- Donald M. Thea (ORCID: https://orcid.org/0000-0002-6933-1030)
- Sudha Basnet (ORCID: https://orcid.org/0000-0001-8433-2499)
- Shamim Qazi (ORCID: https://orcid.org/0000-0002-9688-9259)
- Chris A. Rees (ORCID: https://orcid.org/0000-0001-6449-0377)
- Prakash Mohan Jeena (ORCID: https://orcid.org/0000-0001-9244-6285)
- Clare Cutland (ORCID: https://orcid.org/0000-0001-8250-8307)
- Norman Lufesi (ORCID: https://orcid.org/0000-0001-9667-4293)
- Syed Mohammad Akram uz Zaman
- Juan Manuel Lozano (ORCID: https://orcid.org/0000-0002-3888-9015)
- Tim Colbourn (ORCID: https://orcid.org/0000-0002-6917-6552)
- Gillian A. Levine (ORCID: https://orcid.org/0000-0002-9884-9592)
- Shubhada Hooli (ORCID: https://orcid.org/0000-0003-4596-448X)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-1116-4559)
- Mariam Sylla (ORCID: https://orcid.org/0000-0002-8853-4132)
- Shally Awasthi
- Charles Mwansambo
- Archana Patel
- Brad Gessner
- Joseph L. Mathew
- William B MaLeod
Institutions
- South African Medical Research Council (ZA)
- Boston University (US)
- Boston Children's Hospital (US)
- Centers for Disease Control and Prevention (US)
- World Bank (US)
- Mongolian Academy of Sciences (MN)
- Harvard University (US)
- University of Antananarivo (MG)
- Johns Hopkins University (US)
- Emory University (US)
- Swiss Tropical and Public Health Institute (CH)
- Queensland University of Technology (AU)
- University of Health Science (KH)
- Pfizer (United States) (US)
- Baylor College of Medicine (US)
- University of Basel (CH)
- University of the Witwatersrand (ZA)
- Liverpool School of Tropical Medicine (GB)
- Florida International University (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Cornell University (US)
- Komfo Anokye Teaching Hospital (GH)
- Angkor Hospital for Children (KH)
- Johns Hopkins Medicine (US)
- Research Institute for Tropical Medicine (PH)
- Translational Health Science and Technology Institute (IN)
- King George's Medical University (IN)
- Karolinska Institutet (SE)
- University of Oxford (GB)
- University of Bamako (ML)
- Lata Medical Research Foundation (IN)
- Hospices Civils de Lyon (FR)
- World Health Organization (CH)
- Fondation Mérieux (FR)
- Malawi Government (MW)
- Infant Foundation (AR)
- Ministry of Health (MW)
- Gheskio Centers (HT)
- Children's Healthcare of Atlanta (US)
- University of Bergen (NO)
- University College London (GB)
- Post Graduate Institute of Medical Education and Research (IN)
- All India Institute of Medical Sciences (IN)
- Sharda University (IN)
- Universidad Nacional de Asunción (PY)
- National Research Foundation (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- BMJ Global Health
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1136/bmjgh-2024-017256
- Primary Topic
- Emergency and Acute Care Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation