Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models
Our findings demonstrate that IL-27 expression by oHSV significantly improves antiglioma therapeutic efficacy, enhances CTL effector function, and induces durable immune memory. Thus, IL-27-oHSV may provide a promising therapeutic approach for MGs.
Authors
- Ilse Hernandez-Aguirre
- Yeaseul Kim
- Jack Hedberg (ORCID: https://orcid.org/0000-0002-0914-9480)
- Ravi Dhital (ORCID: https://orcid.org/0000-0001-6180-2128)
- Alexia Martin (ORCID: https://orcid.org/0000-0001-8728-7910)
- Kevin A. Cassady (ORCID: https://orcid.org/0000-0003-2474-9051)
- Do‐Yeon Kim (ORCID: https://orcid.org/0000-0003-2200-7396)
- Uksha Saini
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1136/jitc-2025-012227
- Citations
- 4
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- CancerFree KIDS