A CNTNAP1 Missense Variant Associated With Laryngeal Paralysis and Polyneuropathy in Young Great Dane Dogs
A homozygous missense CNTNAP1 variant (p.G937E, XP_548083.3) has been confirmed in young Great Dane dogs that should expand the genetic testing available for LPPN in this breed and aid in the direction of breeding programs. Both dogs were euthanized because of progression of clinical signs approximately 6 months after the original diagnosis.
Authors
- G. Diane Shelton (ORCID: https://orcid.org/0000-0002-3332-1359)
- Katie M. Minor (ORCID: https://orcid.org/0000-0002-5472-5088)
- Ling Guo (ORCID: https://orcid.org/0000-0001-8394-4338)
- Missy C. Carpentier
- Yuji Kimura
Institutions
- University of Minnesota (US)
- University of California San Diego (US)
- MNGI Digestive Health (US)
- AdventHealth Tampa (US)
Publication Details
- Journal
- Journal of Veterinary Internal Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/jvim.70185
- Citations
- 1
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.84