Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77–101 years)
We found consistent evidence for a combined association of bone and muscle health on all-cause mortality. Randomised controlled trials are now needed to confirm if increasing or preserving bone and muscle mass in old age reduces mortality risk.
Authors
- Eric Orwoll (ORCID: https://orcid.org/0000-0002-8520-7355)
- Peggy M. Cawthon (ORCID: https://orcid.org/0000-0003-4938-9478)
- Jesse Zanker (ORCID: https://orcid.org/0000-0003-3463-6827)
- Gustavo Duque (ORCID: https://orcid.org/0000-0001-8126-0637)
- Andrew J. Burghardt (ORCID: https://orcid.org/0000-0002-6343-4944)
- Ben Kirk (ORCID: https://orcid.org/0000-0002-0176-776X)
- Stephanie Litwack Harrison (ORCID: https://orcid.org/0009-0005-0473-9800)
Institutions
- Oregon Health & Science University (US)
- The University of Melbourne (AU)
- University of California, San Francisco (US)
- McGill University Health Centre (CA)
- California Pacific Medical Center (US)
- Western Health (AU)
- Australian Institute for Musculoskeletal Science (AU)
- Sunshine Hospital (AU)
- Melbourne Health (AU)
- McGill University (CA)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1093/ageing/afaf189
- Citations
- 5
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 8.61
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Advancing Translational Sciences