Syzygium aromaticum Phytoconstituents Target SARS-CoV-2: Integrating Molecular Docking, Dynamics, Pharmacokinetics, and miR-21 rs1292037 Genotyping
The bioactive constituents of <i>Syzygium aromaticum</i> exhibit strong potential as multi-target antivirals, with molecular simulations highlighting caryophyllene's particularly stable interaction with the 7Z4S protein. Methyl eugenol also maintained consistent binding across several SARS-CoV-2 targets. Additionally, the miR-21 rs1292037 polymorphism may influence COVID-19 severity through its role in inflammatory regulation. Together, these results support the combined application of phytochemicals and genetic insights in antiviral research, pending further clinical verification.
Authors
- Safaa Abed Latef Al Meani (ORCID: https://orcid.org/0000-0003-2956-3811)
- Faiza Safi
- Mohammed Salih Al-Janaby (ORCID: https://orcid.org/0000-0002-2831-9246)
- Mustafa Ahmed Muhmood
Institutions
- University of Sfax (TN)
- University of Anbar (IQ)
- University of Al Maarif (IQ)
- Hopital Universitaire Hedi Chaker (TN)
Publication Details
- Journal
- Viruses
- Published
- 2025-07-05
- DOI
- https://doi.org/10.3390/v17070951
- Citations
- 2
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.01