Perception of ‘patient safety culture’ among healthcare professionals in the field of haematopoietic stem cell transplantation and CAR-T therapy: a multicentre cross-sectional observational study by Italian Transplant Group for Bone Marrow Transplant

Adverse events associated with healthcare services in hospitalised patients represent a growing burden, generating significant costs for individuals, healthcare facilities and society. Their clinical and economic impact is particularly critical in the context of haematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor (CAR)-T therapy. A positive safety culture is widely recognised as a crucial factor in reducing hospital errors. This study aimed to evaluate the perception of 'Patient Safety Culture' (PSC) among professionals working in the HSCT and CAR-T therapy fields.A multicentre, cross-sectional observational study was conducted by GITMO. The sample included healthcare professionals (physicians, nurses and others) who had been part of the Transplant Programme for at least 2 years. To assess PSC perception, the validated Italian version of the Hospital Survey on Patient Safety (SOPS V.2.0) from the Agency for Healthcare Research and Quality was used.The survey was completed by 166 professionals from 47 centres (54% participation rate). Binary logistic regression showed that haematologists reported higher PSC perceptions compared with nurses with positive responses exceeding 75%, particularly in dimensions such as 'Teamwork' (nurse OR=0.306, p=0.009), 'Organizational Learning-Continuous Improvement' (nurse OR=0.332, p=0.011), 'Response to Error' (nurse OR=0.360, p=0.024), 'Supervisor Support' (nurse OR=0.160, p<0.001), 'Communication About Error' (nurse OR=0.152, p=0.001) and 'Global Instrument' (nurse OR=0.150, p<0.001).The findings highlight the need for targeted interventions to address discrepancies in PSC perceptions across professional roles, age groups and regions. Enhancing staffing levels and promoting the use of incident reporting systems are critical strategies to strengthen safety culture in HSCT and CAR-T therapy settings.

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Publication Details

Journal
BMJ Open Quality
Published
2025-07-01
DOI
https://doi.org/10.1136/bmjoq-2025-003318
Citations
1
Primary Topic
Patient Safety and Medication Errors
Type
article
Field-Weighted Citation Impact
2.52
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article

Perception of ‘patient safety culture’ among healthcare professionals in the field of haematopoietic stem cell transplantation and CAR-T therapy: a multicentre cross-sectional observational study by Italian Transplant Group for Bone Marrow Transplant

Maria Teresa Lupo Stanghellini, Chiara Visintini, Barbara Guidi, Angelo Michele Carella et al.
1 citations
BMJ Open Quality
Patient Safety and Medication Errors
2.52
article

Perception of ‘patient safety culture’ among healthcare professionals in the field of haematopoietic stem cell transplantation and CAR-T therapy: a multicentre cross-sectional observational study by Italian Transplant Group for Bone Marrow Transplant

Maria Teresa Lupo Stanghellini, Chiara Visintini, Barbara Guidi, Angelo Michele Carella, Valentina De Cecco, Vincenzo M. Grassi, Marco Cioce, Marco Deiana, Alessandra Picardi, Anna Carmagnola, Emilia Lerose, Raffaella Cerretti, Maura Faraci, Carmen Nuzzo, Fabio Lamberti, Anna Mele, Matteo Steduto, Renato Congedo, Patrizia Cornacchione, Stefano Botti, Valentina Zoboli, Angela Iula, Giuseppe Vetrugno, Silvia Finotto, Simona Sica, Giovanni Sperti, Giorgia Gobbi, Michele Cimminiello, Sonia Soave, Massimo Vincenzo Martino, Nicola Mordini, D Bettini, Michele Di Donato, Enrico Dutto, Domenico Buonanno
article en
1 citations

Abstract

Adverse events associated with healthcare services in hospitalised patients represent a growing burden, generating significant costs for individuals, healthcare facilities and society. Their clinical and economic impact is particularly critical in the context of haematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor (CAR)-T therapy. A positive safety culture is widely recognised as a crucial factor in reducing hospital errors. This study aimed to evaluate the perception of 'Patient Safety Culture' (PSC) among professionals working in the HSCT and CAR-T therapy fields.A multicentre, cross-sectional observational study was conducted by GITMO. The sample included healthcare professionals (physicians, nurses and others) who had been part of the Transplant Programme for at least 2 years. To assess PSC perception, the validated Italian version of the Hospital Survey on Patient Safety (SOPS V.2.0) from the Agency for Healthcare Research and Quality was used.The survey was completed by 166 professionals from 47 centres (54% participation rate). Binary logistic regression showed that haematologists reported higher PSC perceptions compared with nurses with positive responses exceeding 75%, particularly in dimensions such as 'Teamwork' (nurse OR=0.306, p=0.009), 'Organizational Learning-Continuous Improvement' (nurse OR=0.332, p=0.011), 'Response to Error' (nurse OR=0.360, p=0.024), 'Supervisor Support' (nurse OR=0.160, p<0.001), 'Communication About Error' (nurse OR=0.152, p=0.001) and 'Global Instrument' (nurse OR=0.150, p<0.001).The findings highlight the need for targeted interventions to address discrepancies in PSC perceptions across professional roles, age groups and regions. Enhancing staffing levels and promoting the use of incident reporting systems are critical strategies to strengthen safety culture in HSCT and CAR-T therapy settings.

BMJ Open QualityVol. 14(3)
Casa Sollievo della Sofferenza (IT), Istituto Giannina Gaslini (IT), Agostino Gemelli University Polyclinic (IT), Ospedale Antonio Cardarelli (IT), Azienda Sanitaria Unità Locale di Reggio Emilia (IT), Ospedale "Santa Maria delle Croci" di Ravenna (IT), Azienda ospedaliera "Bianchi-Melacrino-Morelli" (IT), Azienda Unità Sanitaria Locale di Ferrara (IT), Ospedale San Carlo (IT), Istituto Oncologico Veneto (IT), Meyer Children's Hospital (IT), Bambino Gesù Children's Hospital (IT), Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT), Policlinico Tor Vergata (IT), Policlinico San Matteo Fondazione (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Openalex Percentile: Top 12%
Patient Safety and Medication Errors
2.52
DOIOpen Access PDFOpenAlex
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