Aging disrupts hepatocyte zonation homeostasis in mice and humans
These findings reveal that aging causes loss of distinct hepatic zonation and alters intercellular communication through widespread transcriptional and architectural remodeling of liver cell types. The emergence of bi-zonal hepatocytes and expansion of hepatic zones in aged livers represent key hallmarks of hepatic aging. Our study provides new insights into mechanisms of liver aging and may inform therapeutic strategies targeting age-associated liver dysfunction.
Authors
- Saloni Sinha (ORCID: https://orcid.org/0000-0002-5528-3998)
- Erika Hissong (ORCID: https://orcid.org/0000-0002-2606-6812)
- Robert E. Schwartz (ORCID: https://orcid.org/0000-0002-5417-5995)
- Qurban Ali (ORCID: https://orcid.org/0000-0002-3160-4830)
- Jason Sethiadi
- Tuo Zhang (ORCID: https://orcid.org/0000-0001-5396-918X)
- S. M. Hanna
- Duc Huy T-Nguyen
Institutions
- Cornell College (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1097/hep.0000000000001451
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.29