Liver resection with and without vascular resection versus transplantation for de novo perihilar cholangiocarcinoma
Both LR and RT+LT achieve excellent oncological outcomes in selected patients with de novo perihilar cholangiocarcinoma. Key challenges remain dropouts during neoadjuvant therapy in patients planned for LT and high perioperative mortality for patients undergoing LR. OS doubles in patients undergoing LR+VR compared with dropouts, supporting LR+VR as a viable option for patients who are ineligible for LT. Appropriate patient selection is crucial, as those not undergoing surgery suffer from a dismal prognosis.
Authors
- Julie K. Heimbach (ORCID: https://orcid.org/0000-0002-3567-1328)
- Gregory James Gores (ORCID: https://orcid.org/0000-0003-3151-009X)
- Patrick P. Starlinger (ORCID: https://orcid.org/0000-0002-4666-5337)
- Sumera I. Ilyas (ORCID: https://orcid.org/0000-0002-2709-3003)
- John E. Eaton (ORCID: https://orcid.org/0000-0002-8029-4947)
- Tayyab S. Diwan (ORCID: https://orcid.org/0000-0002-4153-4469)
- Zhihao Li (ORCID: https://orcid.org/0000-0002-5654-7043)
- Timuçin Taner (ORCID: https://orcid.org/0000-0003-0641-2930)
- Susanne G. Warner (ORCID: https://orcid.org/0000-0003-4329-7943)
- David M. Nagorney (ORCID: https://orcid.org/0000-0003-4053-9476)
- Rory L. Smoot (ORCID: https://orcid.org/0000-0001-8543-661X)
- Yawen Dong (ORCID: https://orcid.org/0000-0002-3631-1228)
- V. Podrascanin (ORCID: https://orcid.org/0009-0004-9684-8918)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1097/hep.0000000000001449
- Citations
- 4
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.03