Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation
FFQD may improve insulin resistance, regulate glucose and lipid metabolism, inhibit excessive autophagy, induce macrophage polarization, resist inflammation and oxidative stress, inhibit atherosclerosis, and ultimately improve DMD by activating the RAGE/PI3K/AKT/mTOR and RAP1/PI3K/AKT/FOX01 pathways. Therefore, FFQD may be a promising candidate for DMD treatment.
Authors
- Hai Huang (ORCID: https://orcid.org/0000-0002-2376-0462)
- Shizhao Zhang (ORCID: https://orcid.org/0000-0001-7594-2113)
- Guiyun Li (ORCID: https://orcid.org/0000-0002-0160-1209)
- Hongyan Wu (ORCID: https://orcid.org/0009-0000-7064-9401)
- Jiamin Liu (ORCID: https://orcid.org/0009-0007-9802-5562)
- Pengpeng Liang
- Mei Yan
- Zhang Ye (ORCID: https://orcid.org/0000-0003-3495-5596)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/dmso.s515521
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00