Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients
The impact of corticosteroids, widely prescribed for palliation of cancer-related symptoms, on ICI therapy remains unclear. This study shows that baseline steroid use is a negative independent prognostic factor in patients with NSCLC undergoing ICI therapy and provides insights into the decreased T-cell effector differentiation and utility of predictive blood-based markers by steroids.
Authors
- Junko Matsuzaki (ORCID: https://orcid.org/0000-0002-2555-1234)
- Fumito Ito (ORCID: https://orcid.org/0000-0002-6866-671X)
- Joshua Ni
- Rajeev Sharma (ORCID: https://orcid.org/0000-0003-1342-7153)
- Ryutaro Kajihara (ORCID: https://orcid.org/0000-0003-0908-2543)
- Leslie Contreras
- Robert C. Hsu (ORCID: https://orcid.org/0000-0003-3957-6106)
- Brahm H. Segal (ORCID: https://orcid.org/0000-0001-5043-7380)
- Shirley Ye
- Hongbin Chen (ORCID: https://orcid.org/0000-0002-5086-4769)
- Jorge J. Nieva (ORCID: https://orcid.org/0000-0003-1605-4719)
- Aubree Mades (ORCID: https://orcid.org/0000-0003-4707-9505)
- Joy Sarkar (ORCID: https://orcid.org/0000-0002-7920-1926)
- Eihab Abdelfatah (ORCID: https://orcid.org/0000-0002-5503-8685)
- Takaaki Oba (ORCID: https://orcid.org/0000-0001-8283-4989)
- Ming Li (ORCID: https://orcid.org/0009-0007-9659-8615)
- Angelina Lim (ORCID: https://orcid.org/0000-0001-5508-0392)
- Alexandra Meyer
- Lauren Polyakov
- Ryan Cooper (ORCID: https://orcid.org/0000-0002-5473-2392)
Institutions
- University of Southern California (US)
- Roswell Park Comprehensive Cancer Center (US)
- Hackensack University Medical Center (US)
- Shinshu University (JP)
- USC Norris Comprehensive Cancer Center (US)
- Hackensack Meridian Health (US)
- University at Buffalo, State University of New York (US)
- Kumamoto University (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0051
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- U.S. Department of Defense
- National Cancer Institute