Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms

While most patients demonstrated the capacity to mount an immune response to SARS-CoV-2, treatment with RTX impacted both humoral and CD8+cell responses. Developing vaccines that elicit robust CD8+T cell responses could offer benefits to individuals undergoing ITs for inflammatory rheumatic diseases.

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Publication Details

Journal
RMD Open
Published
2025-07-01
DOI
https://doi.org/10.1136/rmdopen-2025-005673
Primary Topic
Long-Term Effects of COVID-19
Type
article
Field-Weighted Citation Impact
0.00

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article

Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms

Sylvie van der Werf, Jérémie Sellam, Clementina López‐Medina, O. Fogel et al.
RMD Open
Long-Term Effects of COVID-19
article

Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms

Sylvie van der Werf, Jérémie Sellam, Clementina López‐Medina, O. Fogel, Bruno Fautrel, Béatrice Parfait, Jacques Morel, Cyril Planchais, Sylvie Behillil, Corinne Miceli‐Richard, Maxime Beretta, Hugo Mouquet, Hélène Péré, Emmanuel Martin, Sylvain Latour, Jérôme Avouac, Francis Bérenbaum, Thomas Bruneau, Pedro Gonçalves, James P. Di Santo
article en

Abstract

While most patients demonstrated the capacity to mount an immune response to SARS-CoV-2, treatment with RTX impacted both humoral and CD8+cell responses. Developing vaccines that elicit robust CD8+T cell responses could offer benefits to individuals undergoing ITs for inflammatory rheumatic diseases.

RMD OpenVol. 11(3)
Délégation Paris 5 (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Institut Pasteur (FR), Université Paris Cité (FR), Sorbonne Université (FR), Hôpital Cochin (FR), Hôpital Européen Georges-Pompidou (FR), Hôpital Saint-Antoine (FR), Hôpital Européen (FR), Immunité et Cancer (FR), Hospital Universitario Reina Sofía (ES), Hôpital Lapeyronie (FR), Institut des Maladies Génétiques Imagine (FR)
Agence Nationale de la Recherche
Good health and well-being
Openalex Percentile: Top 75%
Long-Term Effects of COVID-19
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