Understanding the Role of Social Negativity in Perceived Life Course Impact and Mental Health Among Women with Endometriosis

<b>Background</b>: Endometriosis is a chronic, inflammatory, estrogen-dependent gynecological disease in which endometrial-like tissue grows in areas outside the uterus. This condition may significantly influence women's life course and mental health. Personal, behavioral, social, and environmental factors play a crucial role in predicting these outcomes. The current study aimed to compare the Perceived Life Course Impact (PLCI) and mental health of women with Endometriosis to those without the disease, as well as to explore the factors associated with PLCI and mental health. <b>Methods</b>: This cross-sectional study surveyed 543 Israeli women (270 with Endometriosis, 273 without). Participants completed a validated questionnaire assessing perceptions of life course impact in several life domains (intimacy and relationships, employment, education) and mental health. Multiple regression analyses were used to identify factors associated with PLCI and mental health among participants. <b>Results</b>: Women with Endometriosis reported a significantly greater negative perceived impact on intimacy and relationships, employment, and education, with poorer mental health, as compared to the control group. Women with Endometriosis also experienced higher social negativity and lower social support. Multiple regression analyses indicated social negativity as a strong predictor of negative PLCI. Additionally, menstrual pain, social support, and healthcare accessibility were found to be significant predictors of both PLCI and mental health. <b>Conclusions</b>: Comprehensive care for women with Endometriosis requires a multidisciplinary approach, with interventions focused on improving healthcare accessibility, enhancing social support networks, and mitigating social negativity within interpersonal environments.