Synthesis of Natural Carbazole Alkaloids: An Update

Carbazoles alkaloids are tricyclic aromatic heterocyclic organic compounds, consisting of a central pyrrole ring fused with two benzene rings. Carbazole derivatives are an important class of nitrogen-containing heterocyclic compounds that are widely found in nature and in synthetic source. These heterocyclic compounds have a broad range of bioactivities and thus, the synthesis of carbazole alakaloid has atracted intensive research interest of chemists. However, review articles on total synthesis of natural carbazole alkaloids in the literature are very limited and quite outdated. This review provides a comprehensive analysis of studies on the synthesis of natural carbazole alkaloids since 2014. More than 90 studies have been summarized. References have been collected from various resources such as Google Scholar, SciFinder, and PubMed. Especially, we tried to focus on total synthesis studies. The article might be useful for chemists who works in synthesis of heterocycles or drug chemistry.