Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD4T mouse model
Our findings suggest that bone marrow-derived inflammation play a critical role in AD-associated inflammation, offering potential targets for therapeutic intervention such as <i>Cst7</i> and <i>Ctsd</i> in bone marrow-derived myeloid cells.
Authors
- Cunxiang Ju
- Junjie Gao (ORCID: https://orcid.org/0000-0003-4820-8524)
- Lufeng Yao
- Guoji Guo (ORCID: https://orcid.org/0000-0002-1716-4621)
- Yao Meng (ORCID: https://orcid.org/0000-0003-0386-6267)
- Yidan Pang (ORCID: https://orcid.org/0000-0002-2286-1069)
- Bingqi Wang (ORCID: https://orcid.org/0000-0002-7692-4299)
- Dongjing Jia
- Chunying Yang (ORCID: https://orcid.org/0000-0001-8188-0860)
- Jiaqi Li (ORCID: https://orcid.org/0000-0002-3218-5930)
- Fei Liu (ORCID: https://orcid.org/0009-0009-6085-2823)
- Lin Du (ORCID: https://orcid.org/0000-0003-2990-1120)
- Changqing Zhang (ORCID: https://orcid.org/0000-0002-7408-4126)
- Fang Ye (ORCID: https://orcid.org/0000-0001-8507-0734)
- Siyuan Zhu (ORCID: https://orcid.org/0000-0002-1743-1953)
- Qi Hao
Institutions
- Ningbo University (CN)
- Shanghai Jiao Tong University (CN)
- Shantou University (CN)
- Ningbo No. 2 Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shanghai Sixth People's Hospital (CN)
- Institute of New Materials (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.jot.2025.06.014
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- Natural Science Foundation of Jiangsu Province