Influence of Deep Brain Stimulation and Dopaminergic Therapy on Intrinsic Preference for Free Choice in Patients With Parkinson’s Disease
STN-DBS enhances free-choice preference by modulating the right mPFC-STN network, suggesting that this hyperdirect pathway influences intrinsic valuation of choice. These results indicate that STN-DBS promotes self-determined behavior even in risky contexts. Furthermore, chronic DAergic therapy may influence sensitivity to intrinsic reward.
Authors
- Jérôme Munuera (ORCID: https://orcid.org/0000-0001-9532-8735)
- Carine Karachi (ORCID: https://orcid.org/0000-0002-4011-6564)
- Nicolas Tempier
- David Bendetowicz (ORCID: https://orcid.org/0000-0002-6310-1250)
- Élodie Hainque (ORCID: https://orcid.org/0000-0001-9049-6246)
- Virginie Czernecki (ORCID: https://orcid.org/0000-0002-0139-7957)
- Gizem Temiz (ORCID: https://orcid.org/0000-0002-4562-2140)
- Brian Lau (ORCID: https://orcid.org/0000-0001-8615-8244)
- Marie‐Laure Welter
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université Paris Sciences et Lettres (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut Jean Nicod (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut du Cerveau (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.bpsc.2025.06.008
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Horizon 2020 Framework Programme