Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review

Immuno-oxidative pathway dysregulation represents convergent processes underlying the pathophysiology of both SZ and aging, contributing to synaptic dysfunction, neuronal damage, and cognitive impairment. Further research in this domain, using an innovative accelerated longitudinal design and novel, advanced neuroimaging techniques, might open new avenues for understanding common pathophysiological mechanisms and developing therapeutic interventions targeting these interconnected pathways.

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Publication Details

Journal
Schizophrenia Bulletin
Published
2025-05-29
DOI
https://doi.org/10.1093/schbul/sbaf099
Citations
2
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
1.16
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article

Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review

Akila Weerasekera, Öngür Dost
2 citations
Schizophrenia Bulletin
Tryptophan and brain disorders
1.16
article

Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review

Akila Weerasekera, Öngür Dost
article en
2 citations

Abstract

Immuno-oxidative pathway dysregulation represents convergent processes underlying the pathophysiology of both SZ and aging, contributing to synaptic dysfunction, neuronal damage, and cognitive impairment. Further research in this domain, using an innovative accelerated longitudinal design and novel, advanced neuroimaging techniques, might open new avenues for understanding common pathophysiological mechanisms and developing therapeutic interventions targeting these interconnected pathways.

Schizophrenia BulletinVol. 52(2)
Harvard University (US), McLean Hospital (US), Imaging Center (US)
Openalex Percentile: Top 23%
Tryptophan and brain disorders
1.16
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