Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review
Immuno-oxidative pathway dysregulation represents convergent processes underlying the pathophysiology of both SZ and aging, contributing to synaptic dysfunction, neuronal damage, and cognitive impairment. Further research in this domain, using an innovative accelerated longitudinal design and novel, advanced neuroimaging techniques, might open new avenues for understanding common pathophysiological mechanisms and developing therapeutic interventions targeting these interconnected pathways.
Authors
- Akila Weerasekera (ORCID: https://orcid.org/0000-0003-0446-7604)
- Öngür Dost
Institutions
- Harvard University (US)
- McLean Hospital (US)
- Imaging Center (US)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1093/schbul/sbaf099
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16