<i>KLF1</i> Knockdown Differentially Regulates γ-Globin Expression: Inhibition in K562 Cells but Reactivation in β-Thalassemia Major Erythrocytes with Erythropoiesis Disruption
<i>KLF1</i> exhibits dual, context-dependent regulation of globin genes, acting as both activator and repressor. These findings suggest that pharmacological targeting of <i>KLF1</i> may not be an optimal therapeutic strategy for β-hemoglobinopathies.
Authors
- Yongrong Lai (ORCID: https://orcid.org/0000-0002-0371-1719)
- Jing Li (ORCID: https://orcid.org/0000-0002-2182-029X)
- Xia Huang (ORCID: https://orcid.org/0000-0001-9668-0503)
- Lingling Shi
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Hemoglobin
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1080/03630269.2025.2514142
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00