High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome

Our findings support the use of selected hdDRS methods to address residual confounding bias when estimating treatment effects with survival outcomes. In particular, the hdDRS method using rate-based risk score modeling on unexposed individuals consistently exhibited the least bias. However, the hdPS method showed comparable performance across most evaluated scenarios. We share reproducible R codes to facilitate researchers' adoption and further evaluation of these methods.

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Journal
Pharmacoepidemiology and Drug Safety
Published
2025-07-01
DOI
https://doi.org/10.1002/pds.70172
Primary Topic
Advanced Causal Inference Techniques
Type
article
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article

High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome

Mohsen Sadatsafavi, Hubert Wong, Mohammad Ehsanul Karim, James C. Johnston et al.
Pharmacoepidemiology and Drug Safety
Advanced Causal Inference Techniques
article

High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome

Mohsen Sadatsafavi, Hubert Wong, Mohammad Ehsanul Karim, James C. Johnston, Victoria Cook, Md. Belal Hossain
article en

Abstract

Our findings support the use of selected hdDRS methods to address residual confounding bias when estimating treatment effects with survival outcomes. In particular, the hdDRS method using rate-based risk score modeling on unexposed individuals consistently exhibited the least bias. However, the hdPS method showed comparable performance across most evaluated scenarios. We share reproducible R codes to facilitate researchers' adoption and further evaluation of these methods.

Pharmacoepidemiology and Drug SafetyVol. 34(7)
University of British Columbia (CA), St. Paul's Hospital (CA), BC Centre for Disease Control (CA), Centre for Advancing Health Outcomes (CA)
Good health and well-being
Openalex Percentile: Top 84%
Advanced Causal Inference Techniques
DOIOpen Access PDFOpenAlex
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High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome — Mohsen Sadatsafavi, Hubert Wong, et al. · Pharmacoepidemiology and Drug Safety (2025) | TGRS Research Map | TGRS