Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment
Results from both the UWL and membrane limited transport conditions demonstrated that the supersaturation ratio (SSR, defined as the ratio of the drug concentration present in solution to its thermodynamic solubility measured in exactly the same media) between donor and acceptor compartments is the real driving force of the transport, when the complexing agent and the drug- HP-β-CD complex does not penetrate the membrane or the permeation of the solubilizing additive through the membrane is relatively slow, so it does not affect the transport of the API substantially.
Authors
- Péter L. Sóti
- Petra Tőzsér (ORCID: https://orcid.org/0009-0007-4725-8884)
- György Tibor Balogh (ORCID: https://orcid.org/0000-0001-8273-1760)
- Bálint Sinkó
- Szabina Kádár (ORCID: https://orcid.org/0000-0002-7818-2145)
- Máté Dobó (ORCID: https://orcid.org/0000-0003-2573-445X)
- Gergő Tóth (ORCID: https://orcid.org/0000-0001-5341-319X)
- Enikő Borbás (ORCID: https://orcid.org/0000-0002-9393-9978)
- Edina Szabó (ORCID: https://orcid.org/0000-0001-9616-5122)
Institutions
- Semmelweis University (HU)
- Budapest University of Technology and Economics (HU)
- Kista Photonics Research Center (SE)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2025-07-05
- DOI
- https://doi.org/10.5599/admet.2753
- Citations
- 1
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Magyar Tudományos Akadémia
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap