Aversion‐resistant alcohol seeking in the human laboratory
These data suggest that aversion-resistant alcohol seeking may stem from the blunted stimulating effects of alcohol, consistent with the low-level response theory driving excessive alcohol seeking, or from acquired tolerance from drinking. This human model of aversion-resistant alcohol seeking can be paired with preclinical models to explore and evaluate new clinical treatment targets.
Authors
- David A. Kareken (ORCID: https://orcid.org/0000-0003-0855-8300)
- J. Taylor Hays (ORCID: https://orcid.org/0000-0002-6110-3121)
- Sean O’Connor (ORCID: https://orcid.org/0000-0001-5427-243X)
- Anna C. S. Garrison (ORCID: https://orcid.org/0000-0002-9966-0409)
- David E. Haines (ORCID: https://orcid.org/0000-0002-5592-8338)
- Melissa A. Cyders (ORCID: https://orcid.org/0000-0003-1990-8337)
- Martin H. Plawecki (ORCID: https://orcid.org/0000-0003-0708-9514)
- Wei Wu (ORCID: https://orcid.org/0000-0001-7955-461X)
- A. Kosobud
- McKenzie R. Cox
- Mayande K. Mlungwana
Institutions
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/acer.70078
- Citations
- 3
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Eli Lilly and Company
- International Business Machines Corporation
- Indiana Clinical and Translational Sciences Institute
- Lilly Endowment
- National Institute on Alcohol Abuse and Alcoholism
- National Center for Advancing Translational Sciences