Endothelin-1 for Early Risk Detection in Sustainable Health Strategies

Purpose: This study examines the role of endothelin-1 (ET-1) as a biomarker for the early identification of endothelial dysfunction and its contribution to aligning national health security with the Sustainable Development Goals (SDGs). Design/methodology/approach: A quantitative approach is employed, using statistical analysis to explore the relationship between ET-1 and key cardiovascular indicators. Data are evaluated to determine the biomarker's potential in supporting preventive healthcare strategies. Findings: The results indicate that ET-1 facilitates early detection of endothelial dysfunction, which precedes hypertension and cardiovascular disease. The use of ET-1 as a predictive indicator enables healthcare systems to shift from curative to preventive strategies, contributing to reduced disease burden and supporting SDG targets related to health financing and sustainability. Practical implications: The findings provide a basis for health policymakers and practitioners to integrate ET-1 screening into national health programmes, particularly in resource allocation and early risk detection. Originality/value: This study offers novel insights into the integrative function of ET-1, highlighting its strategic relevance in preventive health and sustainable development frameworks. It bridges clinical research with policy application in the context of national health resilience.