A human PCLS model of lung injury and repair for discovery and pharmaceutical research
The hAIR model is an effective ex-vivo tool to study early mechanisms of lung repair following injury. By establishing an area of injured tissue adjacent to uninjured tissue, this model mimics the heterogenous pattern of lung injury frequently present in lung diseases. The hAIR model will facilitate mechanistic studies of human lung repair and provides a valuable pre-clinical model for drug testing.
Authors
- Sally Yunsun Kim (ORCID: https://orcid.org/0000-0002-2134-8810)
- Charlotte H. Dean (ORCID: https://orcid.org/0000-0002-8846-5472)
- Matthew Hind (ORCID: https://orcid.org/0000-0002-9966-9446)
- Chun Wai Wong (ORCID: https://orcid.org/0000-0001-8732-1891)
- Esther Bankole
Institutions
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s12931-025-03314-6
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Imperial College London
- National Heart and Lung Institute
- NIHR Imperial Biomedical Research Centre