Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response
Endurance training triggers rapid and persistent chromatin remodeling in muscle, contributing to the transcriptional response to exercise. Our findings suggest that training induces long-lasting epigenetic changes, potentially underpinning muscle memory and improved physiological resilience. These new insights into the molecular mechanisms of muscle adaptation help to understand the training response, and might become relevant in disease prevention.
Authors
- Christoph Handschin (ORCID: https://orcid.org/0000-0003-0603-1097)
- Volkan Adak (ORCID: https://orcid.org/0000-0002-5830-2066)
- Stefan A. Steurer (ORCID: https://orcid.org/0000-0002-7199-3615)
- Aurel B. Leuchtmann (ORCID: https://orcid.org/0000-0002-5800-005X)
- Konstantin Schneider‐Heieck (ORCID: https://orcid.org/0000-0001-8158-9424)
- Laura M de Smalen (ORCID: https://orcid.org/0000-0002-0923-030X)
Institutions
- University of Basel (CH)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1016/j.molmet.2025.102206
- Citations
- 2
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung