Two New Aromatic Milbemycin Metabolites With Unusual Epoxide Moiety From Mutant <i>Streptomyces bingchenggensis</i> HU176
Two new aromatic milbemycin metabolites with unusual epoxide moiety, milbemycin A<sub>5</sub> (1) and 9-O-methylmilbemycin A<sub>5</sub> (2), were isolated from the fermentation broth of mutant Streptomyces bingchenggensis HU176. Their structures were established by extensive spectroscopic analysis including 1D and 2D NMR, HRESIMS data, literature data comparison and NMR calculations. Bioassay test showed that these two new milbemycin metabolites exhibited moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.
Authors
- Huan Qi (ORCID: https://orcid.org/0000-0003-4313-5055)
- Shao‐Yong Zhang
- Jun Huang (ORCID: https://orcid.org/0000-0002-4071-0926)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-2504-3472)
- Jidong Wang (ORCID: https://orcid.org/0000-0003-4098-6209)
- Haiju Xu
- Xiaohan Ren (ORCID: https://orcid.org/0000-0001-5969-608X)
- Ke Yang (ORCID: https://orcid.org/0009-0009-2159-4980)
- X. Jia (ORCID: https://orcid.org/0000-0003-4178-5003)
Institutions
- Huzhou Normal University (CN)
- Hangzhou DAC Biotech (China) (CN)
- Taizhou Vocational and Technical College (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1002/cbdv.202501487
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00