Change in Gasdermin-D gene expression in familial Mediterranean fever compared to healthy children with or without acute infections
We showed a significantly increased GSDMD-∆ for the first time in humans, thereby indicating the distinct role of GSDMD-∆ as a biomarker similar to APRs in FMF attacks. It was even higher than levels detected during acute infections, supporting the functional involvement of GSDMD-∆ in FMF attacks. GSDMD-∆ correlated with APRs but not with serum IL-1β and IL-18 levels.
Authors
- Dilan İnan
- Zeynep Birsin Özçakar (ORCID: https://orcid.org/0000-0002-6376-9189)
- Sevil Oskay Halaçlı (ORCID: https://orcid.org/0000-0003-1101-1779)
- İsmail Yaz (ORCID: https://orcid.org/0000-0001-5278-7456)
- Pınar Özge Avar-Aydın (ORCID: https://orcid.org/0000-0002-7469-109X)
- Deniz Çağdaş (ORCID: https://orcid.org/0000-0003-2213-4627)
Institutions
- Ankara University (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- The Turkish Journal of Pediatrics
- Published
- 2025-07-05
- DOI
- https://doi.org/10.24953/turkjpediatr.2025.5389
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00