Association between C677T variant of methylene tetrahydrofolate reductase and hypospadias risk in Algeria
This study reports, for the first time, an association between the MTHFR gene C677T variant and hypospadias in the Algerian population. The findings suggest a strong association between the MTHFR C677T variant and susceptibility to hypospadias. Identified risk factors such as intrauterine growth restriction, gestational hypertension, rural residency, and the MTHFR C677T variant contribute valuable insights into the multifaceted etiology of hypospadias in this population.
Authors
- Yacine Benhizia
- Rayene Achou (ORCID: https://orcid.org/0009-0004-0709-0130)
- Brahim Djoudi (ORCID: https://orcid.org/0000-0002-7924-2939)
- Djalila Chellat-Rezgoune
- Karima Sifi (ORCID: https://orcid.org/0009-0000-7132-5150)
- S. Touabti
- Rania Laouar (ORCID: https://orcid.org/0000-0002-4392-5156)
- Meroua Horchi
Institutions
- University Frères Mentouri Constantine 1 (DZ)
- University Ferhat Abbas of Setif (DZ)
- Centre Hospito Universitaire de Sétif (DZ)
- University of Constantine 3 (DZ)
Publication Details
- Journal
- The Turkish Journal of Pediatrics
- Published
- 2025-07-05
- DOI
- https://doi.org/10.24953/turkjpediatr.2025.6049
- Primary Topic
- Urological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00