Autologous Blood Patch Pleurodesis for Persistent Pneumothorax in Emphysematous Lung: Salvage Success After Chemical Failure

Persistent air leaks (PALs) present a significant challenge in patients with underlying structural lung abnormalities, such as emphysema. Conventional interventions, including chemical pleurodesis, may be ineffective or poorly tolerated in this population. We present a case of a high-risk patient with refractory pneumothorax successfully managed with autologous blood patch pleurodesis (ABPP). This approach demonstrated rapid resolution of air leak and complete lung re-expansion without surgical intervention. The case underscores ABPP's potential as a safe, bedside alternative in selected patients, particularly those with incomplete pleural apposition or high operative risk.