A case study and literature analysis of an uncommon instance of metachronous non-Hodgkin lymphoma in a patient with colon cancer

Lymphoma can develop before and complicate colorectal cancer in the same patient. However, occurrence of lymphoma years after the complete treatment of colorectal cancer is extremely rare. We here report a case of a 55-year-old gentleman diagnosed with adenocarcinoma of colon treated by standard protocol of surgery, and chemotherapy, later after 10 years of treatment completion, was diagnosed with generalized lymphadenopathy suggestive of non-Hodgkin lymphoma. He was treated with six cycles of chemotherapy (RCHOP regimen). The major concern for multiple primaries is that it is easy to miss and may be misdiagnosed as metastatic disease. Correct diagnosis and early treatment are of utmost importance.