Investigating the eye in Down syndrome as a window to Alzheimer’s disease: the REVEAL protocol – a clinical cross-sectional study
The study gained a favourable opinion from Health and Social Care Research Ethics Committee A (REC reference 22/NI/0158; approved on 2 December 2022; Amendment 22/0064 Amend 1, 5 April 2023; Amendment 22/0064 Amend 2; 23 May 2024; Amendment 22/0064 Amend 3; 25 June 2024; Amendment 22/0064 Amend 4; 16 January 2025; Amendment 22.0064 Amend 5; 9 May 2025; Amendment 22.0064 Amend 6; 9 June 2025). The study has also been reviewed and approved by the School of Biomedical Sciences Research Ethics Filter Committee within Ulster University. Findings from the REVEAL study will be presented to academic audiences at international conferences and peer-reviewed publications in targeted high-impact journals after data collection and analysis are complete. Dissemination activities will also include presentations at public events.
Authors
- Lajos Csincsik (ORCID: https://orcid.org/0000-0001-5243-7536)
- Julie‐Anne Little (ORCID: https://orcid.org/0000-0001-5242-8066)
- Elaine Murray (ORCID: https://orcid.org/0000-0003-0170-6809)
- Tünde Pető (ORCID: https://orcid.org/0000-0001-6265-0381)
- Imre Lengyel (ORCID: https://orcid.org/0000-0001-7467-2174)
- Aoife Mary Louise Hunter (ORCID: https://orcid.org/0000-0002-0150-4126)
- André Strydom (ORCID: https://orcid.org/0000-0002-2502-6704)
- Kathryn J. Saunders (ORCID: https://orcid.org/0000-0002-9289-5731)
- Sarah D. Atkinson (ORCID: https://orcid.org/0000-0002-3208-8794)
- Jamie Mitchell
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- Queen's University Belfast (GB)
- University of Wisconsin–Madison (US)
- University of Ulster (GB)
- King's College London (GB)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-098285
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ulster University
- Medical Research Council